Pathogenesis of prostate cancer and hormone refractory prostate cancer
نویسندگان
چکیده
منابع مشابه
Prognostic indicators in hormone refractory prostate cancer.
Prognostic factors in hormone refractory prostate cancer currently are of limited use to clinicians. Although studies have identified several factors that predict for poor survival in patients, most are either retrospective, or nonrandomized. Therefore, large prospective, randomized trials are needed to validate the significance of these factors. In addition, these indicators are largely descri...
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Over 60 years ago, Huggins and Hodges discovered androgen deprivation as an effective first-line therapy for metastatic prostate cancer. This leads to significant cancer control but in almost all men prostate cancer ultimately progresses to a hormone-refractory (HRPC) state resulting in significant morbidity and eventual death. In 2004, two landmark studies using docetaxel based chemotherapy de...
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Cancers of the prostate are categorized as follows: 1)hormone-naive (never having previously received hormone manipulation); 2)androgen-dependent (having received hormonal manipulation but a less than continuous application, i.e., intermittent androgen blockade or with an agent that does not produce a castrate testosterone level, i.e., antiandrogen); 3)androgen independent (progressive disease ...
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only orchiectomy is still commonly used today either as a single therapy or in combination regimens. hypophysectomy & adrenalectomy showed such devastating effects on the endocrine equilibrium as to be inconsistent with an acceptable quality of life or even with survival. chemical adrenalectomy was also tried with drugs (eg. aminoglutethmide, spironolactone) leading to consequences superimposab...
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ژورنال
عنوان ژورنال: Indian Journal of Urology
سال: 2007
ISSN: 0970-1591
DOI: 10.4103/0970-1591.30265